Gel Permeation Chromatograph - Scattering Method

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When measuring Molecular Weight, Triple or Tetra detection SEC/GPC has become the preferred method of measurement as there is no need for lengthy column calibration. It employs a concentration detector, a viscometer and a light scattering detector acting in concert to give absolute molecular weight, molecular size (to less than 1 nm) and intrinsic viscosity, as well as information on conformation, branching and aggregation.

Static Light Scattering (SLS) is a technique that measures the intensity of light scattered by the sample to obtain the average molecular weight of a macromolecule like a polymer or protein. Measurements are most commonly performed as part of a GPC/SEC system. The advantage of a Malvern Viscotek SLS system is that molecular weight is measured directly from the light scattering detector. This avoids the need to calibrate to GPC elution volume and gives true molecular weight distributions.